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KMID : 0861120080120020027
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Korean Journal of Oriental Preventive Medicine
2008 Volume.12 No. 2 p.27 ~ p.35
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Herbal Toxicological Effects on Rats’ Fetus -Focusing on Ojeoksan-
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Park Hae-Mo
Shin Heon-Tae
Lee Sun-Dong
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Abstract
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Purpose : The experiments was undertaken to evaluate the effects of Ojeoksan-herbal medicine, in rats’ fetus
Methods : Female Sprague-Dawley rats were orally administered with the Ojeoksan at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Approximately live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol.
Results : Neonatal body weight and number of fetus of Ojeoksan group were increased to that of control group. The fetuses of dams treated with Ojeoksan didn’t showed external malformation. Vertebral and sternal skeletal variations were observed in Ojeoksan administered group, but compared to the control, those skeletal variations were insignificant. There were no significant changes in number of ribs, cervical, thoracic, lumber, sacral and caudal
Conclusion : From these results, it can be concluded that Ojeoksan showed no toxicity effects on number of live fetuses. There were no significant changes in skeletal variations were showed in vertebrate and sternum, Ojeoksan weren’t shown significant changes in bone malformation. We need more precise study to investigate the mechanism of early or late resorption by the herbal medicines such as Ojeoksan.
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KEYWORD
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Ojeoksan, herbal medicine, toxicity, variation, malformation
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